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Phosphohexose Isomerase Dificiency (PHI) is also known as phosphoglucose isomerase deficiency or Glucose-6-phosphate isomerase deficiency , and is a hereditary enzyme deficiency. PHI is the second most frequent erthoenzyopathy in glycolysis besides pyruvate kinase deficiency , and is associated with non-spherocytic haemolytic anaemia of variable severity. [15] [16] This disease is centered on the glucose-6-phosphate protein. This protein can be found in the secretion of some cancer cells. [17] PHI is the result of a dimeric enzyme that catalyses the reversible interconversion of fructose-6-phosphate and gluose-6-phosphate. [15]

Vitamin D
Vitamin D, which we produce naturally from sun exposure, is essential to the healthy functioning of every organ in the body. Vitamin D deficiency has become an epidemic of modern indoor living, so a supplement is necessary. Look for naturally sourced (from lanolin or fish liver oil) Vita min D3 (cholecalciferol) , which is the type of Vitamin D made in skin in response to sunlight. It is more biologically active than Vitamin D2 ( ergocalciferol ). However, it is NOT vegetarian. Vegetarians should use Vitamin D2, which is derived from plant sources and will be labeled "vegetarian vitamin D." For the latest research on Vitamin D, go to .

Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. [2]

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