Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs an update

The term allergy was originally defined by Clemens Von Pirquet as “an altered capacity of the body to react to a foreign substance,” which was an extremely broad definition that included all immunological reactions. Allergy is now defined in a much more restricted manner as “disease following a response by the immune system to an otherwise innocuous antigen .” Allergy is one of a class of immune system responses that are termed hypersensitivity reactions . These are harmful immune responses that produce tissue injury and may cause serious disease. Hypersensitivity reactions were classified into four types by Coombs and Gell ( Fig. ). Allergy is often equated with type I hypersensitivity (immediate-type hypersensitivity reactions mediated by IgE ), and will be used in this sense here.

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What one might think is a chlorine allergy might actually be underlying asthma, exercise-induced bronchoconstriction (EIB) or bronchospasm. A runny nose might be due to other underlying allergy problems. People with asthma, EIB and allergic rhinitis, who already have sensitive airways, might also have the following symptoms: 1) Coughing, especially at night, with exercise, or when laughing, 2) Trouble breathing, 3) A tight feeling in the chest, 4) Wheezing a squeaky or whistling sound, 5) Runny nose, 6) Itching, 7) Sneezing, 8) Stuffy nose due to blockage or congestion.

CONCLUSION
With the acquired knowledge of the role that causative factors play in localizing and initiating dentin hypersensitivity, prevention strategies may now be included in the dental hygiene care plan. Active management will involve a combination of chairside and oral self-care therapies. Multiple therapeutic modalities are designed to treat dentin hypersensitivity, including products to impede nerve conduction of the pain stimulus, products to mechanically occlude dentin tubules, and calcium-containing products de­signed to generate plugs in the tubules utilizing a remineralization mechanism.
Although dentin hypersensitivity is not the enigma it once was, there is still much to learn about the condition itself, the management of risk, and prevention behaviors. Our profession is strategically positioned to not only evaluate but also to educate to improve the comfort and quality of life for our dental hygiene patients.

Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs an update

hypersensitivity reactions to nonsteroidal anti-inflammatory drugs an update

CONCLUSION
With the acquired knowledge of the role that causative factors play in localizing and initiating dentin hypersensitivity, prevention strategies may now be included in the dental hygiene care plan. Active management will involve a combination of chairside and oral self-care therapies. Multiple therapeutic modalities are designed to treat dentin hypersensitivity, including products to impede nerve conduction of the pain stimulus, products to mechanically occlude dentin tubules, and calcium-containing products de­signed to generate plugs in the tubules utilizing a remineralization mechanism.
Although dentin hypersensitivity is not the enigma it once was, there is still much to learn about the condition itself, the management of risk, and prevention behaviors. Our profession is strategically positioned to not only evaluate but also to educate to improve the comfort and quality of life for our dental hygiene patients.

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