Oral equivalent to unasyn

The 15 gram vial may be reconstituted with either 92 mL Sterile Water for Injection or % Sodium Chloride Injection. The diluent should be added in two separate aliquots in a suitable work area, such as a laminar flow hood. Add 50 mL of solution, shake to dissolve. Then add an additional 42 mL and shake. The solution should be allowed to stand after dissolution to allow any foaming to dissipate in order to permit visual inspection for complete solubilization. The resultant solution will have a final concentration of approximately 100 mg/mL ampicillin and 50 mg/mL sulbactam. The closure may be penetrated only one time after reconstitution, if needed, using a suitable sterile transfer device or dispensing set that allows for measured dispensing of the contents.

A double-blind, randomized, clinical study compared amoxicillin and clavulanate potassium for oral suspension, 600 mg/ mg per 5 mL (90/ mg/kg/day, divided every 12 hours) to amoxicillin and clavulanate potassium(45/ mg/kg/day, divided every 12 hours) for 10 days in 450 pediatric patients (3 months to 12 years) with acute otitis media. The primary objective of the study was to compare the safety of amoxicillin and clavulanate potassium for oral suspension, 600 mg/ mg per 5 mL to amoxicillin and clavulanate potassium. There was no statistically significant difference between treatments in the proportion of patients with 1 or more adverse events. The most frequently reported adverse events for amoxicillin and clavulanate potassium for oral suspension, 600 mg/ mg per 5 mL and the comparator of amoxicillin and clavulanate potassium were coughing (% versus %), vomiting (% versus %), contact dermatitis (., diaper rash, 6% versus %), fever (% versus %), and upper respiratory infection (% versus %), respectively. The frequencies of protocol-defined diarrhea with amoxicillin and clavulanate potassium for oral suspension, 600 mg/ mg per 5 mL (%) and Amoxicillin and Clavulanate Potassium (%) were similar (95% confidence interval on difference: −% to %). Only 2 patients in the group treated with amoxicillin and clavulanate potassium for oral suspension, 600 mg/ mg per 5 mL and 1 patient in the group treated with amoxicillin and clavulanate potassium 600 mg/ mg per 5 mL were withdrawn due to diarrhea.

Acute bacterial sinusitis may be the complication of an initial viral illness. The primary bacterial isolates are S. aureus, S. pneumoniae, Haemophilus influenzae , and Moraxella catarrhalis . 9 The . Food and Drug Administration (FDA) has labeled gatifloxacin, moxifloxacin, sparfloxacin, and levofloxacin for use in the treatment of acute bacterial sinusitis. Clinical trials comparing fluoroquinolones with amoxicillin-clavulanate potassium (Augmentin), cefuroxime axetil (Ceftin), and clarithromycin (Biaxin) have demonstrated the efficacy of the quinolone antibiotics. 9 However, we believe that quinolones should not be used as first-line agents in the treatment of acute bacterial sinusitis because of the potential for development of bacterial resistance.

2. Fosfomycin (PO)
Bactericidal agent that is excreted into the urine and inhibits cell wall synthesis by interfering with peptidoglycan synthesis.
Spectrum: Broad spectrum vs Gram positive including MRSA, VRE; Gram negative including Pseudomonas and some ESBL’s . 
Used for: Uncomplicated urinary tract infections in women, especially in those with history of resistant bugs.  Given as a one-time mega-dose of 3 g (excreted into urine and achieves high levels there for several days.   Sometimes used for complicated UTI’s in males with resistant pathogens (3 g PO q3 days x several doses), although this is an off-label use.

Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure , liver dysfunction , those taking diuretics and ACE inhibitors , and the elderly. Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state.

Oral equivalent to unasyn

oral equivalent to unasyn

2. Fosfomycin (PO)
Bactericidal agent that is excreted into the urine and inhibits cell wall synthesis by interfering with peptidoglycan synthesis.
Spectrum: Broad spectrum vs Gram positive including MRSA, VRE; Gram negative including Pseudomonas and some ESBL’s . 
Used for: Uncomplicated urinary tract infections in women, especially in those with history of resistant bugs.  Given as a one-time mega-dose of 3 g (excreted into urine and achieves high levels there for several days.   Sometimes used for complicated UTI’s in males with resistant pathogens (3 g PO q3 days x several doses), although this is an off-label use.

Media:

oral equivalent to unasynoral equivalent to unasyn