The newer antihistamines, or second generation antihistamines, are thought by many to be the best antihistamines available. They are less likely to cause the drowsiness associated with the older medications, so they are often referred to as “nonsedating.” Although claritin has been recently made available over-the-counter, most of the nonsedating antihistamines require a prescription. In general, if a newer anti histamine does not work well for a patient, doctors will then resort to the original, first generation antihistamines.
The newer, second generation antihistamines include:
• zyrtec (cetirizine)
The foreskin represents at least a third of the penile skin. It protects the glans from abrasion and contact with clothes. The foreskin also increases sexual pleasure by sliding up and down on the shaft, stimulating the glans by alternately covering and exposing it. This can occur during masturbation or intercourse. Friction is minimized, and supplementary lubrication is not needed. Without the foreskin, the glans skin, which is normally moist mucous membrane, becomes dry and thickens considerably in response to continued exposure. This change reduces its sensitivity.
Third-generation cephalosporins are broad-spectrum antimicrobial agents useful in a variety of clinical situations. No one cephalosporin is appropriate for all infectious disease problems. Cefotaxime and ceftizoxime have the best gram-positive coverage of the third-generation agents. Ceftazidime and cefoperazone are the only third-generation drugs that provide antipseudomonal coverage. Ceftriaxone's long half-life allows for once-daily dosing, making ceftriaxone an excellent drug for outpatient antibiotic therapy of community-acquired infections. Ceftriaxone is also useful for the treatment of Lyme disease and sexually transmitted diseases. The third-generation cephalosporins except for cefoperazone penetrate cerebrospinal fluid and are indicated for the treatment of bacterial meningitis. Their proven record of clinical efficacy, favorable pharmacokinetics, and low frequency of adverse effects make third-generation cephalosporins the preferred antibiotic in many clinical situations.