For the pet owner, a serious discussion with your dog's vet is critical in understanding proper use of prednisone and its possible side effects. The list is long and one has to weigh the possible results against the possible side effects. In the past, it was the pet owner's insistence on immediate relief of symptoms that made prednisone the drug of choice for anti-inflammatory action. Today's pet owners are better educated and wiser about long term issues that can be detrimental. Other drugs and treatment options make it possible to alleviate symptoms in the mildly allergic dog without resorting to steroid treatment and should be tried for a period of weeks, even months, before giving up. These options would include a better understanding of day to day attention to environmental factors, improved diet that will build up immunity and often the simple matter of keeping the dog inside in an air conditioned environment during seasonal allergic reactions. When steroid treatment is absolutely needed, the sooner the drug regimen can be completed the better. While steroids may alleviate symptoms, they are not a cure.
The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile .    The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation , by Arthur Nobile and coworkers.  They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone . 
I have never written a review on anything really, but I thought it was important in this case. I have been dealing with arthritis for probably 15 years. I was essentially given two choices: the first is take Allopurinol and hope it prevents me from getting sprouts. However, I would have to take a 20 mg pill every day, and this medication has upset my stomach in the past. Option two is to treat an outbreak when it occurs with the medication. I went this route, and took Colchicine, which is the medication to treat this. The problem is that it never seemed to work, and I recently had a terrible gout attack. I got Prednisone and it really worked miracles. I was probably 70% better after one full day, and now almost 100% after three days. I am more than satisfied with this medication!