For decades many athletes who use anabolic steroids have supplemented with the SERM Tamoxifen ( Nolvadex ) to combat such issues. Nolva, as it is commonly known acts to block the estrogen from binding to the receptors; it does not reduce estrogen as is commonly thought by many who take it. However, while this is a solid prevention measure, for many it is not enough and only an aromatase inhibitor will do. An aromatase inhibitor will actually reduce the amount of estrogen in the body and bind it what’s left. While perhaps not completely accurate but to give you an idea, for the prevention of Gynecomastia when steroids are present look at Nolva like Aspirin and aromatase inhibitors like morphine; far stronger. The two most common aromatase inhibitors that will in most cases get the job done include Anastrozole ( Arimidex ) and Femara ( Letrozole .)
All individuals, whether male or female, possess both female hormones (estrogens) and male hormones (androgens). During puberty, levels of these hormones may fluctuate and rise at different levels, resulting in a temporary state in which estrogen concentration is relatively high. Studies regarding the prevalence of gynecomastia in normal adolescents have yielded widely varying results, with prevalence estimates as low as 4% and as high as 69% of adolescent boys. These differences probably result from variations in what is perceived to be normal and the different ages of boys examined in the studies.
Gynecomastia is a common adverse effect of bicalutamide (Casodex) therapy that may prompt some men to discontinue prostate cancer treatment. Tamoxifen has been recommended as a preventive agent for gynecomastia in these patients. A double-blind study of 282 men randomized to receive 20 mg of tamoxifen once per day with bicalutamide or bicalutamide alone found that after six months, gynecomastia and breast pain were significantly reduced in men who received tamoxifen ( versus percent in the control group). 41 An Italian randomized controlled trial of 80 participants also found that 20 mg of tamoxifen once per week is as effective as 20 mg once per day. 42