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The exact dosing instructions for nitric oxide supplement is not known. However, most supplements contain an average dose of grams of L-arginine and L-citrulline. We suggest you follow a process known as tolerance mapping to understand just how much nitric acid is required for your body. The process is simple. All you have to do is start with a small dose in Week 1. During the first week, make sure you note down the benefits and side effects that you are feeling. Once your body has adjusted to the lowest dose possible, you can then increase the dosing until you start feeling beneficial effects. Gradually, your body starts adjusting to the supplement and you will hit your optimal dose. However, the temporary recommendations for the supplement that you can take 2000mg-6000mg per day for optimum effects. Please note that overdosing is possible as dose variations can happen due to physiological differences. In case you notice diarrhea, vomiting, weakness, and nausea, stop the supplement immediately and consult your personal physician. Please note that liquids are absorbed much faster than solids and dosages for liquids will be lower than that of solid preparations.

However, in December 2004 the United States the 14-member Food and Drug Administration (FDA) advisory committee, plus voting consultants, for Reproductive Health Drugs unanimously rejected Procter and Gamble's fast-track request for Intrinsa citing concerns about off-label use . In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In Australia, post-menopausal women can use Organon testosterone implants which have to be surgically inserted and last from three to six months. [3]

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