Lapatinib is a 4-anilinoquinazoline kinase inhibitor of the intracellular tyrosine kinase domains of both epidermal growth factor receptor (HER1/EGFR/ERBB1) and human epidermal growth factor receptor type 2 (HER2/ERBB2)with a dissociation half-life of ≥300 minutes. Lapatinib inhibits ERBB-driven tumor cell growth in vitro and in various animal models. An additive effect was demonstrated in an in vitro study when lapatinib and 5-florouracil (the active metabolite of capecitabine) were used in combination in the 4 tumor cell lines tested. The growth inhibitory effects of lapatinib were evaluated in trastuzumab-conditioned cell lines. Lapatinib retained significant activity against breast cancer cell lines selected for long-term growth in trastuzumab-containing medium in vitro. These in vitro findings suggest non-cross-resistance between these two agents.
Governor Murkowski offered other jobs to Palin, and in February 2003 she accepted an appointment to the Alaska Oil and Gas Conservation Commission , which oversees Alaska's oil and gas fields for safety and efficiency.  While she had little background in the area, she said she wanted to learn more about the oil industry and was named chair of the commission and ethics supervisor.    By November 2003 she was filing nonpublic ethics complaints with the state attorney general and the governor against a fellow commission member, Randy Ruedrich, a former petroleum engineer and at the time the chair of the state Republican Party .  He was forced to resign in November 2003.  Palin resigned in January 2004 and put her protests against Ruedrich's "lack of ethics" into the public arena   by filing a public complaint against Ruedrich,  who was then fined $12,000. She joined with Democratic legislator Eric Croft  in complaining that Gregg Renkes, then the attorney general of Alaska ,  had a financial conflict of interest in negotiating a coal exporting trade agreement.   Renkes also resigned his post.  
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